Publications



これまでの研究論文

(1) Matsunaga T, Monobe K, Aoki S, Identification of a Chemical Inhibitor with a Novel Scaffold Targeting Decaprenylphosphoryl-β-D-Ribose Oxidase (DprE1), Infect Disord Drug Targets, 2023. (責任著者) (査読有り).

(2) Masamune Takeuchi, Mio Teshima, Saya Okubo, Prof. Dr. Shunsuke Aoki, In silico and in vitro Identification of Compounds with Dual Pharmacological Activity against Metionyl-tRNA Synthetase and Isoleucyl-tRNA Synthetase of Staphylococcus aureus, 2023. (責任著者) (査読有り).

(3) Kuriki K, Matsumoto R, Ijichi C, Taira J, Aoki S, Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure, Chemical Biology Letters, 2022. (責任著者) (査読有り).

(4) Taira J, Murakami K, Monobe K, (...), Sakamoto H, Aoki S, Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs, Journal of Antibiotics75(10), pp. 552-558, 2022. (責任著者) (査読有り).

(5) Nakashima J, Takeuchi M, Kawamoto S, (...), Taira J, Aoki S, Establishing a parallel compound screening method and identifying novel antimicrobial compounds targeting Staphylococcus aureus dihydrofolate reductase Open Access, Journal of Applied Pharmaceutical Science12(8), pp. 36-47, 2022. (責任著者) (査読有り).

(6) Kuriki K, Taira J, Kuroki M, Sakamoto H, Aoki S, Computer-assisted screening of mycobacterial growth inhibitors: Exclusion of frequent hitters with the assistance of the multiple target screening method, International Journal of Mycobacteriology10(3), pp. 307-311, 2021. (責任著者) (査読有り).

(7) Junichi Taira, Tomohiro Umei, Keitaro Inoue, Mitsuru Kitamura, Francois Berenger, James C. Sacchettini, Hiroshi Sakamoto, Shunsuke Aoki, "Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening", The Journal of Antibiotics, 2020. (責任著者) (査読有り).

(8) Junichi Taira, Toshiki Nagano, Mitsuru Kitamura, Miho Yamaguchi, Hiroshi Sakamoto, Shunsuke Aoki, "Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by in silico structure-based drug screening ", The International Journal of Mycobacteriology, 2020. (責任著者) (査読有り).

(9) Junichi Taira, Koji Morita, Shotaro Kawashima, Tomohiro Umei, Hiroki Baba, Taira Maruoka, Hideyuki Komatsu, Hiroshi Sakamoto, James C Sacchettini and Shunsuke Aoki "Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening", The Journal of Antibiotics, 2017. (責任著者) (査読有り).

(10) Junichi Taira, Takashi Ito, Hitomi Nakatani, Tomohiro Umei, Hiroki Baba, Shotaro Kawashima, Taira Maruoka, Hideyuki Komatsu, Hiroshi Sakamoto,Shunsuke Aoki "In silico Structure‑based Drug Screening of Novel Antimycobacterial Pharmacophores by DOCK‑GOLD Tandem Screening", The International Journal of Mycobacteriology, 2017. (責任著者) (査読有り).

(11) Katsuya S, Aoki S, Kunio M. "Hepatocyte growth factor and Met in drug discovery.", J. Biochem., 157(5), 271-284, 2015.(査読あり)

(12) Kanetaka H, Koseki Y, Taira J, Umei T, Komatsu H, Sakamoto H, Gulten G, Sacchettini JC, Kitamura M, Aoki S. "Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach.", Eur J Med Chem. 94: p378-385 2015. (責任著者) (査読有り).

(13) Kobayashi M, Kinjo T, Yuji Koseki, Christina R Bourne, William W Barrow, Aoki S. "Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase." , J Chem Inf Model., 54:p1242–1253, 2014. (責任著者) (査読有り)

(14) Koseki Y, Aoki S. "Computational Medicinal Chemistry for Rational Drug Design: Identification of Novel Chemical Structures with Potential Anti-Tuberculosis Activity." , Curr Top Med Chem., 14: p176-188, 2014. (責任著者) (査読有り)

(15) Kinjo T, Koseki Y, Kobayashi M, Yamada A, Morita K, Yamaguchi K, Tsurusawa R, Gulten G, Komatsu H, Sakamoto H, Sacchettini JC, Kitamura M, Aoki S. "Identification of Compounds with Potential Antibacterial Activity against Mycobacterium through Structure-Based Drug Screening.", J Chem Inf Model. 2013. (責任著者) (査読有り).

(16) Koseki Y, Kinjo T, Kobayashi M, Aoki S. "Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.", Eur J Med Chem. 2013 . (責任著者) (査読有り).

(17) Koseki Y, Kinjo T, Kuroki M, Aoki S. "Aberrant structures of Parkinson’s disease-associated ubiquitin C-terminal hydrolase L1 predicted by molecular dynamics" , Chemical Physics Letters, 2012.(責任著者) (査読有り).

(18) Izumizono Y, Arevalo S, Koseki Y, Kuroki M, Aoki S. Identification of novel potential antibiotics for tuberculosis by in silico structure-based drug screening. Eur J Med Chem. 46: p1849-56. 2011. (責任著者) (査読有り).

(19) Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Ogiuchi H, Okano T, Ando T. PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration. J Tissue Eng Regen Med. 2011 in press. (査読有り)

(20) Nishikawa K, Ayukawa K, Hara Y, Wada K, Aoki S .Endothelin/endothelin-B receptor signals regulate ventricle-directed interkinetic nuclear migration of cerebral cortical neural progenitors. Neurochem Int. 58:p261-72.2011. (責任著者) (査読有り)

(21) Mitsui T, Hirayama K, Aoki S, Nishikawa K, Uchida K, Matsumoto T, Kabuta T, Wada K. Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening.. Neurochem Int. 56: p679-686, 2010. (査読有り)

(22) Sasaki R, Watanabe Y, Yamato M, Aoki S, Okano T, Ando T. Surgical anatomy of the swine face. Lab Anim. 44: p359-63. 2010. (査読有り)

(23) Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Ogiuchi H, Okano T, Ando T. A protocol for immunofluorescence staining of floating neurospheres. Neurosci Lett. 479: p126-7. 2010. (査読有り)

(24) Kimiwada T, Sakurai M, Ohashi H, Aoki S, Tominaga T, Wada K. Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells. Neurochem Int. 54: p227-285, 2009.(査読有り)

(25) Gamo K, Kiryu-Seo S, Konishi H, Aoki S, Matsushima K, Wada K, Kiyama H. G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity. J Neurosci. 28: p11980-11988. 2008. (査読有り)

(26) Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Okano T, Ogiuchi H. Tubulation with dental pulp cells promotes facial nerve regeneration in rats. Tissue Eng Part A. 14: p1141-1147. 2008. (査読有り)

(27) Kabuta T, Furuta A, Aoki S, Furuta K, Wada K. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem. 283: p23731-23738. 2008. (査読有り)

(28) Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Okano T, Ogiuchi H. Neurosphere generation from dental pulp of adult rat incisor. Eur J Neurosci. 27: p538-548. 2008. (査読有り)

(29) Kabuta T, Setsuie R, Mitsui T, Kinugawa A, Sakurai M, Aoki S, Uchida K, Wada K. Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum Mol Genet. 17: p1482-1496. 2008. (査読有り)

(30) Hirayama K, Aoki S, Nishikawa K, Matsumoto T, Wada K. Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg. Med. Chem. 15:p6810-6818. 2007. (責任著者) (査読有り)

(31) Ohashi H, Nishikawa K, Ayukawa K, Hara Y, Nishimoto M, Kudo Y, Abe T, Aoki S, Wada K. Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells. Eur. J. Pharmacol. 573:p20-28. 2007.(責任著者)(査読有り)

(32) Noda M, Kariura Y, Pannasch U, Nishikawa K, Wang L, Seike T, Ifuku M, Kosai Y, Wang B, Nolte C, Aoki S, Kettenmann H, Wada K. Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia. J Neurochem. 101:p397-410. 2007. (査読有り)

(33) Tanabe K, Gamo K, Aoki S, Wada K, Kiyama H. Melanocortin receptor 4 is induced in nerve-injured motor and sensory neurons of mouse. J Neurochem. 101:p1145-52. 2007. (査読有り)

(34) Nishimoto M, Furuta A, Aoki S, Kudo Y, Miyakawa H, Wada K. PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells. Glia. 55:p317-327. 2007. (査読有り)

(35) Setsuie R, Wang YL, Mochizuki H, Osaka H, Hayakawa H, Ichihara N, Li H, Furuta A, Sato Y, Sun YJ, Kwon J, Kabuta T, Yoshimi K, Aoki S, Mizuno Y, Noda M, Wada K. Dopaminergic cell loss in transgenic mice expressing the Parkinson’s disease-associated UCH-L1 I93M mutant. Neurochem Int. 50:p119-129. 2007. (査読有り)

(36) Sun YJ, Nishikawa K, Yuda H, Wang YL, Osaka H, Fukazawa N, Naito A, Kudo Y, Wada K, Aoki S. Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation. Mol Cell Biol. 26, p6923-6935, 2006. (責任著者) (査読有り)

(37) Sato A, Arimura Y, Manago Y, Nishikawa K, Aoki K, Wada E, Suzuki Y, Osaka H, Setsuie R, Sakurai M, Amano T, Aoki S, Wada K, Noda M. Parkin potentiates ATP-induced currents due to activation of P2X receptors in PC12 cells. J Cell Physiol. 209:p 172-182. 2006. (査読有り)

(38) Amano T, Aoki S, Setsuie R, Sakurai M, Wada K, Noda M. Identification of a novel regulatory mechanism for norepinephrine transporter activity by the IP3 receptor. Eur J Pharmacol. 536:p62-68. 2006. (責任著者). (査読有り)

(39) Fukazawa N, Ayukawa K, Nishikawa K, Ohashi H, Ichihara N, Hikawa Y, Abe T, Kudo Y, Kiyama H, Wada K, Aoki S. Identification and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res. 1070:p1-14. 2006. (責任著者). (査読有り)

(40) Sakurai M, Ayukawa K, Setsuie R, Nishikawa K, Hara Y, Ohashi H, Nishimoto M, Abe T, Kudo Y, Sekiguchi M, Sato Y, Aoki S, Noda M, Wada K. Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. J Cell Sci. 119:p162-171. 2006. (査読有り)

(41) Naito S, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu HM, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K. Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering. Biochem Biophys Res Commun. 339:p717-725. 2006. (査読有り)

(42) Wang YL, Liu W, Sun YJ, Kwon J, Setsuie R, Osaka H, Noda M, Aoki S, Yoshikawa Y, Wada K. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice. Mol Reprod Dev. 73:p40-49. 2006. (査読有り)